Spongy Degeneration and Cerebellar Ataxia
SDCA is an inherited neurodegenerative disease of Belgian Shepherd dogs that clinically manifests as cerebellar dysfunction in young dogs.
Age of Onset: 4-7 weeks of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over the course of a few weeks
Clinical signs worsen over the course of a few weeks
Clinical Signs:
Behavioral/Mental Awareness
Seizures
Posture/Appearance
Wide-based stance
Movement
Generalized whole body tremors
Ataxia
Paresis to paralysis
Limb spasticity
Intention tremor
Bunny-hopping gait
Proprioception
Delayed postural reactions
Cranial Nerves
Central blindness (absent menace response)
Behavioral/Mental Awareness
Seizures
Posture/Appearance
Wide-based stance
Movement
Generalized whole body tremors
Ataxia
Paresis to paralysis
Limb spasticity
Intention tremor
Bunny-hopping gait
Proprioception
Delayed postural reactions
Cranial Nerves
Central blindness (absent menace response)
Multi-focal: brainstem, cerebellum, and spinal cord
Autosomal recessive inheritance:
Spongy Degeneration with Cerebellar Ataxia 1 (SDCA1): KCNJ10 mutation
For breed specific genetic testing follow the links below:
Spongy Degeneration with Cerebellar Ataxia 1 (SDCA1):
https://embarkvet.com/products/dog-health/health-conditions/spongy-degeneration-with-cerebellar-ataxia-1-sdca1-sesame-east-syndrome/
https://www.gensoldx.com/tests/spongy-degeneration-with-cerebellar-ataxia-1-sdca1/
https://www.genomia.cz/en/test/sdca1/
Spongy Degeneration with Cerebellar Ataxia 1 (SDCA1): KCNJ10 mutation
For breed specific genetic testing follow the links below:
Spongy Degeneration with Cerebellar Ataxia 1 (SDCA1):
https://embarkvet.com/products/dog-health/health-conditions/spongy-degeneration-with-cerebellar-ataxia-1-sdca1-sesame-east-syndrome/
https://www.gensoldx.com/tests/spongy-degeneration-with-cerebellar-ataxia-1-sdca1/
https://www.genomia.cz/en/test/sdca1/
To read more about this disease click below:
