Neonatal Encephalopathy
Neonatal encephalopathy is an inherited progressive brain disease affecting the cortical white matter and cerebellum. It is often associated with seizures and severe neurologic signs presenting soon after birth. Dogs often succumb to their clinical signs or are euthanized by 7 weeks of age.
Age of Onset: Clinical signs present at birth
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen rapidly over 1-7 weeks, progressing from weakness to ataxia and generalized seizures. Dogs often succumb to their clinical signs or are euthanized by 7 weeks of age.
Clinical signs worsen rapidly over 1-7 weeks, progressing from weakness to ataxia and generalized seizures. Dogs often succumb to their clinical signs or are euthanized by 7 weeks of age.
Clinical Signs:
Posture and Appearance
Small stature
Movement
Weak at birth
Ataxia
Whole-body tremor
Hypermetria
Proprioception
Decreased postural reactions
Cranial Nerves
Absent menace response OU
Posture and Appearance
Small stature
Movement
Weak at birth
Ataxia
Whole-body tremor
Hypermetria
Proprioception
Decreased postural reactions
Cranial Nerves
Absent menace response OU
Intracranial - diffuse
Autosomal recessive mutation in ATF2
For breed-specific genetic testing, follow the link below:
https://vgl.ucdavis.edu/test/news
For breed-specific genetic testing, follow the link below:
https://vgl.ucdavis.edu/test/news
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