Gangliosidosis Type 1 (GM1)
Gangliosidosis (GM1) is a deficiency in the enzyme beta-galactosidase which causes defects in the catabolism of gangliosides resulting in their accumulation in neuron lysosomes.
Age of Onset: Less than 7 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs begin with progressive motor dysfunction and progress over the course of 6-12 months before culminating in death.
Clinical signs begin with progressive motor dysfunction and progress over the course of 6-12 months before culminating in death.
Clinical Signs:
Posture and Appearance
Broad-based stance
Movement
Ataxia
Dysmetria
Hypermetria
Head Tremor
Spastic Paraplegia or Tetraplegia
Other
Death
Posture and Appearance
Broad-based stance
Movement
Ataxia
Dysmetria
Hypermetria
Head Tremor
Spastic Paraplegia or Tetraplegia
Other
Death
Brain and spinal cord
Autosomal recessive inheritance of mutation of the GLB1 gene encoding the β-galactosidase enzyme
For breed specific genetic testing, please click the link below:
vgl.ucdavis.edu/test/gm1-shiba-inu
www.genomia.cz/en/test/gm1-shiba/
https://www.animalabs.com/shop/dog/gangliosidosis-type-1-gm1--shiba-inu-type/
For breed specific genetic testing, please click the link below:
vgl.ucdavis.edu/test/gm1-shiba-inu
www.genomia.cz/en/test/gm1-shiba/
https://www.animalabs.com/shop/dog/gangliosidosis-type-1-gm1--shiba-inu-type/
To read more about this disease click below:
