Alexander Disease (Myeloencephalopathy/Fibrinoid Encephalomyelopathy/Rosenthal Fiber Myelopathy)
An extremely rare primary degeneration of nervous elements with a range of clinical signs and disease patterns.
Age of Onset: 3-6 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs may worsen over time
Clinical signs may worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Alterations in personality or behavior
Aversion to touch
Reluctance to move
Excessive fear
Depressed
Comatose
Posture and Appearance
Tremor
*Head tilt
Seizure-like activity
Thoracic limb extension
Opisthotonos
Reddened mucus membranes
Stiffness
Movement
Ataxia
Drifting to the side
Myotonic spasms
Flaccid paraparesis to tetraparesis
Proprioception
Slow postural reflexes
Cranial Nerves
Reduced menace response
Decreased physiologic nystagmus
Difficulty swallowing
Spinal Reflexes
Reduced/absent or increased spinal reflexes
Special Functions (e.g. respiration; urination)
Urinary incontinence
Respiratory failure
Vocalization abnormalities
Other
Increased body temperature
Behavioral/Mental Awareness
Alterations in personality or behavior
Aversion to touch
Reluctance to move
Excessive fear
Depressed
Comatose
Posture and Appearance
Tremor
*Head tilt
Seizure-like activity
Thoracic limb extension
Opisthotonos
Reddened mucus membranes
Stiffness
Movement
Ataxia
Drifting to the side
Myotonic spasms
Flaccid paraparesis to tetraparesis
Proprioception
Slow postural reflexes
Cranial Nerves
Reduced menace response
Decreased physiologic nystagmus
Difficulty swallowing
Spinal Reflexes
Reduced/absent or increased spinal reflexes
Special Functions (e.g. respiration; urination)
Urinary incontinence
Respiratory failure
Vocalization abnormalities
Other
Increased body temperature
Diffuse CNS
Unknown
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