Neuronal Ceroid Lipofuscinosis
Neuronal ceroid lipofuscinosis are a group of lysosomal storage disorders characterized by intracellular accumulations resulting in progressive neuronal degeneration.
Age of Onset: 1-9 years (most are less than 2 years of age)
Sex Predisposition: Any sex of dog can be affected
Clinical Course:
Clinical signs progress over the course of several months where the dog may be unable to stand or walk.
Clinical signs progress over the course of several months where the dog may be unable to stand or walk.
Clinical Signs:
Behavioral/Mental Awareness
Seizures
Personality change
Aggression
Hyperactivity
Loss of learned behavior
Lack of focus
Self-mutilation
Movement
Ataxia
Head tremors
Tetraparesis
Loss of balance
Proprioception
Proprioceptive deficits
Cranial Nerves
Visual impairment
Absent menace response (OU)
Behavioral/Mental Awareness
Seizures
Personality change
Aggression
Hyperactivity
Loss of learned behavior
Lack of focus
Self-mutilation
Movement
Ataxia
Head tremors
Tetraparesis
Loss of balance
Proprioception
Proprioceptive deficits
Cranial Nerves
Visual impairment
Absent menace response (OU)
Intracranial - diffuse
Autusomal recessive CLN6 gene mutation
For breed specific genetic testing, click the link below:
eurovetgene.com/neuronal-ceroid-lipofuscinosis-ncl6-schapendoes
For breed specific genetic testing, click the link below:
eurovetgene.com/neuronal-ceroid-lipofuscinosis-ncl6-schapendoes
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