Metabolic Encephalopathy (Succinic Semialdehyde Dehydrogenase Deficiency)
Metabolic encephalopathy caused by succinic semialdehyde dehydrogenase deficiency results in the malfunction of the GABA (neurotransmitter) metabolic pathway, causing neurologic dysfunction.
Age of Onset: Less than 10 weeks of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs may worsen over time or remain stable after onset
Clinical signs may worsen over time or remain stable after onset
Clinical Signs:
Behavioral/Mental Awareness
Abnormal vocalization
Altered behavior
Difficult being aroused from sleep
Seizures
Movement
Mild generalized ataxia
Thoracic limb hypermetria
Proprioception
Delayed proprioception in all four limbs
Cranial Nerves
Absent menace response
Behavioral/Mental Awareness
Abnormal vocalization
Altered behavior
Difficult being aroused from sleep
Seizures
Movement
Mild generalized ataxia
Thoracic limb hypermetria
Proprioception
Delayed proprioception in all four limbs
Cranial Nerves
Absent menace response
Multifocal central nervous system (bilaterally symmetrical lesions of the cerebrum, brainstem, and cerebellum predominantly affecting the grey matter)
Homozygous missense variant in ALDH5A1
For breed specific genetic testing, click the link(s) below:
vgl.ucdavis.edu/test/saluki_enchephalopathy
www.genomia.cz/en/test/ssadhd/
For breed specific genetic testing, click the link(s) below:
vgl.ucdavis.edu/test/saluki_enchephalopathy
www.genomia.cz/en/test/ssadhd/
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