Juvenile Onset Polyneuropathy (LPN1/ Stockard's Paralysis)
Juvenile-onset polyneuropathy is an early-onset neurodegenerative disorder of dogs affecting multiple peripheral nerves.
Age of Onset: Less than 4 years of age
Sex Predisposition: Males may be more commonly affected than females (Ekenstedt, 2014).
Clinical Course:
Clinical signs worsen over time
Clinical signs worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Exercise intolerance
Movement
Ataxia
Spinal Reflexes
Hyporeflexia
Special Functions (e.g. respiration; urination)
Laryngeal paralysis (inspiratory stridor and dyspnea)
Painful Reactions
Cutaneous hypalgesia
Muscle Atrophy
Appendicular muscle atrophy
Behavioral/Mental Awareness
Exercise intolerance
Movement
Ataxia
Spinal Reflexes
Hyporeflexia
Special Functions (e.g. respiration; urination)
Laryngeal paralysis (inspiratory stridor and dyspnea)
Painful Reactions
Cutaneous hypalgesia
Muscle Atrophy
Appendicular muscle atrophy
Peripheral nerves
Autosomal recessive ARHGEF10 gene mutation
For breed-specific genetic testing, click the links below:
vetmed.umn.edu/research/research-labs/canine-genetics-lab/canine-genetics-testing/saint-bernard-laryngeal
www.genomia.cz/en/test/lppn/
For breed-specific genetic testing, click the links below:
vetmed.umn.edu/research/research-labs/canine-genetics-lab/canine-genetics-testing/saint-bernard-laryngeal
www.genomia.cz/en/test/lppn/
To read more about this disease click below:
