Acquired Polyneuropathy/Laryngeal Paralysis Complex
Late-onset laryngeal paralysis and polyneuropathy is an idiopathic disease of older large breed dogs resulting in progressive “length-dependent” degeneration of neurons.
Age of Onset: Greater than 4 years of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over the course of several months to years
Clinical signs worsen over the course of several months to years
Clinical Signs:
Behavioral/Mental Awareness
Exercise-intolerance
Movement
Progressive paraparesis
Collapse
Ataxia
High-stepping gait
Spinal Reflexes
Hyporeflexia
Special Functions (e.g. respiration; urination)
Inspiratory stridor
Voice change
Muscle Atrophy
Appedicular muscle atrophy
Behavioral/Mental Awareness
Exercise-intolerance
Movement
Progressive paraparesis
Collapse
Ataxia
High-stepping gait
Spinal Reflexes
Hyporeflexia
Special Functions (e.g. respiration; urination)
Inspiratory stridor
Voice change
Muscle Atrophy
Appedicular muscle atrophy
Diffuse peripheral nerve
Autosomal recessive CNTNAP1 gene (LPPN3) mutation
For breed-specific genetic testing, click the link below:
vetmed.umn.edu/research/research-labs/canine-genetics-lab/canine-genetics-testing/saint-bernard-laryngeal
www.genomia.cz/en/test/lppn/
https://embarkvet.com/products/dog-health/health-conditions/laryngeal-paralysis-and-polyneuropathy/
For breed-specific genetic testing, click the link below:
vetmed.umn.edu/research/research-labs/canine-genetics-lab/canine-genetics-testing/saint-bernard-laryngeal
www.genomia.cz/en/test/lppn/
https://embarkvet.com/products/dog-health/health-conditions/laryngeal-paralysis-and-polyneuropathy/
To read more about this disease click below:
