Neuronal Vacuolation (POANV- Polyneuropathy, Ocular Abnormalities, and Neuronal Vacuolation)
POANV (Polyneuropathy, Ocular Abnormalities, and Neuronal Vacuolation) is an inherited neurodegenerative disorder resulting in selective spinal cord white matter degeneration.
Age of Onset: 2-4 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over time. The clinical course begins with visual abnormalities, progressing to regurgitation and ataxia over 2-6 months.
Clinical signs worsen over time. The clinical course begins with visual abnormalities, progressing to regurgitation and ataxia over 2-6 months.
Clinical Signs:
Movement
**Ataxia
**Tetraparesis
Proprioception
**Proprioceptive deficits (pelvic limbs > thoracic limbs)
Cranial Nerves
Bilaterally absent menace response
Strabismus
Spinal Reflexes
Hyperreflexia of all four limbs
Crossed-extensor reflex
Muscle Hypertonicity
Special Functions (e.g. respiration; urination)
Regurgitation
**Inspiratory stridor/laryngeal paralysis
Dyspnea
Other
Microphthalmia
Cataracts
Persistent pupillary membranes
Movement
**Ataxia
**Tetraparesis
Proprioception
**Proprioceptive deficits (pelvic limbs > thoracic limbs)
Cranial Nerves
Bilaterally absent menace response
Strabismus
Spinal Reflexes
Hyperreflexia of all four limbs
Crossed-extensor reflex
Muscle Hypertonicity
Special Functions (e.g. respiration; urination)
Regurgitation
**Inspiratory stridor/laryngeal paralysis
Dyspnea
Other
Microphthalmia
Cataracts
Persistent pupillary membranes
Spinal cord (sensory > motor), eyes, and vagus nerve
Autosomal recessive RAB3GAP1 Mutation
For breed-specific genetic testing, click the link(s) below:
https://embarkvet.com/resources/https-embarkvet-com-resources-genetic-health-testing-for-rottweilers/
For breed-specific genetic testing, click the link(s) below:
https://embarkvet.com/resources/https-embarkvet-com-resources-genetic-health-testing-for-rottweilers/
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