Necrotizing Meningoencephalitis
Necrotizing meningoencephalitis (NME) is a non-infectious inflammatory condition under the spectrum of meningoencephalitis of unknown origin. In NME, the lymphoplasmacytic inflammation is primarily distributed throughout the deep cerebral white matter and diencephalon. The inflammation can be distributed bilaterally, but is often worse in one hemisphere.
Age of Onset: Typically occurs in animals less than 5 years of age
Sex Predisposition: Any sex of dog can be affected
Clinical Course:
Clinical signs often present acutely and progress over time
Clinical signs often present acutely and progress over time
Clinical Signs:
Behavioral/Mental Awareness
Behavioral changes
Generalized seizures
Lethargy
Decreased appetite
Movement
Head turning and circling to one side
Ataxia/Abnormal gait
Proprioception
Proprioceptive deficit (contralateral)
Cranial Nerves
Menace deficit (contralateral)
Central vestibular signs (head tilt, nystagmus, vestibular strabismus)
Behavioral/Mental Awareness
Behavioral changes
Generalized seizures
Lethargy
Decreased appetite
Movement
Head turning and circling to one side
Ataxia/Abnormal gait
Proprioception
Proprioceptive deficit (contralateral)
Cranial Nerves
Menace deficit (contralateral)
Central vestibular signs (head tilt, nystagmus, vestibular strabismus)
Intracranial
Unknown
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