Startle Disease (Hyperekplexia)
Startle disease is a disorder of glycine receptors characterized by episodes of hypertonia and apnea triggered by stimuli such as noise and/or touch.
Age of Onset: First weeks of life
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs are sporadic, in these dogs sudden contraction of extensor muscles is triggered by some external stimulus.
Clinical signs are sporadic, in these dogs sudden contraction of extensor muscles is triggered by some external stimulus.
Clinical Signs:
Behavioral/Mental Awareness
Sensitivity to stimulus
Posture and Appearance
Cyanosis
Movement
Episodic generalized hypertonia
Tremor
Special Functions (e.g. respiration; urination)
Apnea
Behavioral/Mental Awareness
Sensitivity to stimulus
Posture and Appearance
Cyanosis
Movement
Episodic generalized hypertonia
Tremor
Special Functions (e.g. respiration; urination)
Apnea
Diffuse CNS
Autosomal recessive inheritance of SLC6A5 gene mutation
For breed-specific information, follow the links below:
https://labogen.com/en/erbkrankheiten-hund/startle-disease/
https://www.laboklin.co.uk/laboklin/showGeneticTest.jsp?testID=8191
For breed-specific information, follow the links below:
https://labogen.com/en/erbkrankheiten-hund/startle-disease/
https://www.laboklin.co.uk/laboklin/showGeneticTest.jsp?testID=8191
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