Holoprosencephaly
Holoprosencephaly is a malformation of the forebrain characterized by the absence of two separate cerebral hemispheres and midline structures, due to incomplete separation, and the development of hydrocephalus
Age of Onset: Less than 2 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over time
Clinical signs worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Intermittent resource guarding (food)
Inappropriate vocalization
Altered mentation (ranged from lethargic to spastic and aggressive)
Lethargy
Coprophagia
Hypodypsia (with hypernatremia)
Pica
Movement
Ataxia
Circling
Slight forelimb hypermetria
Special Functions (e.g. respiration; urination)
Intermittent coughing
Other
Other congenital developmental abnormalities (cryptorchidism, retained deciduous teeth, hypoplastic penis)
Behavioral/Mental Awareness
Intermittent resource guarding (food)
Inappropriate vocalization
Altered mentation (ranged from lethargic to spastic and aggressive)
Lethargy
Coprophagia
Hypodypsia (with hypernatremia)
Pica
Movement
Ataxia
Circling
Slight forelimb hypermetria
Special Functions (e.g. respiration; urination)
Intermittent coughing
Other
Other congenital developmental abnormalities (cryptorchidism, retained deciduous teeth, hypoplastic penis)
Intracranial- supratentorial
Unknown
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