Muscular Dystrophy (Sarcoglycan Deficient; Limb Girdle Muscular Dystrophy)
Muscular dystrophies are examples of degenerative myopathic conditions of both dogs and cats. Sarcoglycan deficient muscular dystrophies occur due to dysfunction of sarcoglycan membrane proteins.
Age of Onset: 7-17 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over the course of a few months
Clinical signs worsen over the course of a few months
Clinical Signs:
Behavioral/Mental Awareness
Lethargy
Movement
Exercise intolerance
Short-stepped gait
“Stilted”
“Stiff”
Cranial Nerves
Tongue hypertrophy
Special Functions (e.g. respiration; urination)
Drooling
Dysphagia
Regurgitation
Muscle Atrophy
Generalized muscle atrophy
Behavioral/Mental Awareness
Lethargy
Movement
Exercise intolerance
Short-stepped gait
“Stilted”
“Stiff”
Cranial Nerves
Tongue hypertrophy
Special Functions (e.g. respiration; urination)
Drooling
Dysphagia
Regurgitation
Muscle Atrophy
Generalized muscle atrophy
Diffuse neuromuscular
Autosomal recessive SGCA gene mutation
For breed specific genetic testing, click the link below:
vetmed.umn.edu/research/research-labs/canine-genetics-lab/canine-genetics-testing/sarcoglycan-deficient-muscular
For breed specific genetic testing, click the link below:
vetmed.umn.edu/research/research-labs/canine-genetics-lab/canine-genetics-testing/sarcoglycan-deficient-muscular
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