Hypomyelination (Congenital Tremor Syndrome)
Hypomyelination syndrome is characterized by failure to generate a normal myelin sheath-axon relationship within the central nervous system.
Other terms for this syndrome include “shaker pup”, “congenital tremor”, “shaker”, and “trembler” syndromes.
Other terms for this syndrome include “shaker pup”, “congenital tremor”, “shaker”, and “trembler” syndromes.
Age of Onset: 2-8 weeks of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs often worsen with excitement or stress and disappear with sleep. The tremor and ataxia may remain stagnant or may improve over time, almost completely resolving by a few years of age.
For Samoyeds and Springer Spaniels, signs are often progressive and is often a lethal condition
Clinical signs often worsen with excitement or stress and disappear with sleep. The tremor and ataxia may remain stagnant or may improve over time, almost completely resolving by a few years of age.
For Samoyeds and Springer Spaniels, signs are often progressive and is often a lethal condition
Clinical Signs:
Movement
Generalized muscle tremors
Ataxia
Dysmetria
Head bobbing
Spinal Reflexes
Depressed patellar reflexes
Movement
Generalized muscle tremors
Ataxia
Dysmetria
Head bobbing
Spinal Reflexes
Depressed patellar reflexes
Central nervous system (diffuse) – white matter
Unknown
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