Leonberger Polyneuropathy/Laryngeal Paralysis Complex
An inherited degenerative disease of Leonbergers affecting the peripheral nerves. This disease has also been noted to bear similar presentation to Charcot-Marie-Tooth (CMT) disease in humans.
Age of Onset: 1-9 years of age but younger animals are more typically affected
Sex Predisposition: Males are twice as affected as females
Clinical Course:
Clinical signs may worsen over time
Clinical signs may worsen over time
Clinical Signs:
Movement
Hypermetria
Cranial Nerves
Facial nerve paralysis
Decreased gag reflex
Spinal Reflexes
Reduced spinal reflexes
Special Functions (e.g. respiration; urination)
Laryngeal paresis or paralysis
Muscle Atrophy
Distal muscle atrophy
Movement
Hypermetria
Cranial Nerves
Facial nerve paralysis
Decreased gag reflex
Spinal Reflexes
Reduced spinal reflexes
Special Functions (e.g. respiration; urination)
Laryngeal paresis or paralysis
Muscle Atrophy
Distal muscle atrophy
Peripheral nerves
Leonberger Polyneuropathy has been categorized into several genetically distinct variants with similar clinical signs.
Leonberger Polyneuropathy Type 1: Suspected X-linked autosomal recessive mutation in ARHGEF10 gene
Leonberger Polyneuropathy Type 2: Autosomal dominant mutation in GJA9 gene
Leonberger Polyneuroapthy Type 3: Autosomal recessive mutation in CNTNAP1 gene
For breed specific genetic testing follow the links below:
https://vetmed.umn.edu/research/research-labs/canine-genetics-lab/canine-genetics-testing/leonberger-health-panel
https://embarkvet.com/products/dog-health/health-conditions/juvenile-onset-polyneuropathy-leonberger-polyneuropathy-1-lpn1/http://www.leonberger-database.com/lpn_e.html
Leonberger Polyneuropathy Type 1: Suspected X-linked autosomal recessive mutation in ARHGEF10 gene
Leonberger Polyneuropathy Type 2: Autosomal dominant mutation in GJA9 gene
Leonberger Polyneuroapthy Type 3: Autosomal recessive mutation in CNTNAP1 gene
For breed specific genetic testing follow the links below:
https://vetmed.umn.edu/research/research-labs/canine-genetics-lab/canine-genetics-testing/leonberger-health-panel
https://embarkvet.com/products/dog-health/health-conditions/juvenile-onset-polyneuropathy-leonberger-polyneuropathy-1-lpn1/http://www.leonberger-database.com/lpn_e.html
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