Central Axonopathy/Labrador Retriever Axonopathy
A primary degenerative spinal cord disease found in younger animals.
Age of Onset: 3-4 weeks of age
Sex Predisposition: Any sex of animal can be affected.
Clinical Course:
Clinical signs worsen over time
Clinical signs worsen over time
Clinical Signs:
Posture and Appearance
Pelvic limbs short-stepped (strided), adducted, crouched and tended to collapse and sway to the side, which often results in falling
Stiff and mildly abducted forelimbs (wide-based)
Significant difficulty righting themselves to a sternal posture from lateral recumbency
Movement
Difficulty using pelvic limbs at time of first being able to walk
Hypermetria in both forelimb and hindlimb
Dysmetric quality of voluntary movements
Bunny hopping gait
Unable to walk or stand without assistance
Progressively slow or static
Slowness or Inability to readily stand
Mild hypertonia
Proprioception
No hopping postural reactions in any limb
Other
Some dogs showed progressive locomotive deficiency only, while others developed visual deficiency only, or a combination of both
Posture and Appearance
Pelvic limbs short-stepped (strided), adducted, crouched and tended to collapse and sway to the side, which often results in falling
Stiff and mildly abducted forelimbs (wide-based)
Significant difficulty righting themselves to a sternal posture from lateral recumbency
Movement
Difficulty using pelvic limbs at time of first being able to walk
Hypermetria in both forelimb and hindlimb
Dysmetric quality of voluntary movements
Bunny hopping gait
Unable to walk or stand without assistance
Progressively slow or static
Slowness or Inability to readily stand
Mild hypertonia
Proprioception
No hopping postural reactions in any limb
Other
Some dogs showed progressive locomotive deficiency only, while others developed visual deficiency only, or a combination of both
Spinal cord - Dorsolateral funiculus, Fasciculus gracilis, Ventral funiculi
Unknown
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