Exercise-Induced Metabolic Myopathy/Mitochondrial Myopathy
Mitochondrial myopathy is caused by abnormal mitochondrial function/metabolism. Organs that are most dependent on oxidative metabolism are most severely affected.
Age of Onset: 7 -42 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs may progressively worsen
Clinical signs may progressively worsen
Clinical Signs:
Movement
Generalized weakness
Exercise-intolerance
Painful Reactions
Diffuse myalgia
Muscle Atrophy
Atrophy of the front and hind limbs
Other
Brownish discoloration of urine
Movement
Generalized weakness
Exercise-intolerance
Painful Reactions
Diffuse myalgia
Muscle Atrophy
Atrophy of the front and hind limbs
Other
Brownish discoloration of urine
Diffuse muscle
Suspected autosomal recessive inheritance of nonsense variant in the ACADVL gene
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