Mitochondrial (Fission) Encephalopathy
Mitochondrial encephalopathy is caused by abnormal mitochondrial function/metabolism. Organs that are most dependent on oxidative metabolism are most severely affected.
Age of Onset: 6 months - 6 years of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs may progress
Clinical signs may progress
Clinical Signs:
Behavioral/Mental Awareness
Behavior abnormalities
Seizures
Posture and Appearance
Head tilt
Head tremor
Extensor rigidity of thoracic limbs
Wide based stance
Movement
Ataxia
Hypermetric gait
Loss of balance
Spastic tetraparesis
Weakness
Cranial Nerves
Absent menace response
Nystagmus
Visual defects
Pain Sensation
Facial hypalgesia
Behavioral/Mental Awareness
Behavior abnormalities
Seizures
Posture and Appearance
Head tilt
Head tremor
Extensor rigidity of thoracic limbs
Wide based stance
Movement
Ataxia
Hypermetric gait
Loss of balance
Spastic tetraparesis
Weakness
Cranial Nerves
Absent menace response
Nystagmus
Visual defects
Pain Sensation
Facial hypalgesia
Intracranial
Suspected autosomal recessive inheritance of in-frame deletion in canine PITRM1 gene
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