Dysautonomia
Primary dysautonomia is a degenerative disease of autonomic nerves primarily manifesting as parasympathetic dysfunction in addition to some signs of sympathetic and somatic dysfunction.
Age of Onset: Typically onset around 3 years of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Variable - in some patients clinical signs result in fatal consequences while other dogs will resolve spontaneously
Variable - in some patients clinical signs result in fatal consequences while other dogs will resolve spontaneously
Clinical Signs:
Behavioral/Mental Awareness
Lethargy
Anorexia
Photophobia
Posture and Appearance
Ocular appearance (keratoconjunctivitis, corneal ulceration, blepharospasm)
Nasal discharge
Movement
Paresis
Cranial Nerves
Mydriasis
Elevated third eyelid
Reduced pupillary light reflexes
Xerostomia
Spinal Reflexes
Dilated anal sphincter
Special Functions (e.g. respiration; urination)
Distended and easily expressible urinary bladder
Muscle Atrophy
Distal limb muscle atrophy
Other
Vomiting or regurgitation
Reduced gastrointestinal motility
Megacolon
Tenesmus
Dysuria
Coughing/dyspnea
Bradycardia
Weak peripheral pulses
Behavioral/Mental Awareness
Lethargy
Anorexia
Photophobia
Posture and Appearance
Ocular appearance (keratoconjunctivitis, corneal ulceration, blepharospasm)
Nasal discharge
Movement
Paresis
Cranial Nerves
Mydriasis
Elevated third eyelid
Reduced pupillary light reflexes
Xerostomia
Spinal Reflexes
Dilated anal sphincter
Special Functions (e.g. respiration; urination)
Distended and easily expressible urinary bladder
Muscle Atrophy
Distal limb muscle atrophy
Other
Vomiting or regurgitation
Reduced gastrointestinal motility
Megacolon
Tenesmus
Dysuria
Coughing/dyspnea
Bradycardia
Weak peripheral pulses
Diffuse peripheral nerve (autonomic)
Unknown
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