Cerebellar Abiotrophy/Cerebellar Cortical Abiotrophy/Cerebellar Cortical Degeneration/Cerebellar Degeneration
Cerebellar abiotrophy results from a loss of vital substance for continued life of the neuron. Many of these diseases are associated with loss of purkinje cells.
Age of Onset: Clinical signs may be present from birth to 6 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs typically worsen over time
Clinical signs typically worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Incessant crying
Posture and Appearance
Periodic opisthotonus
Vertical nystagmus
Positional nystagmus
Movement
Hypermetria
Pelvic limb stiffness
Pelvic limb ataxia
Inability to stand
Ataxia
Head tremor
Rolling on side
Unable to remain in a sternal position
Intention tremor
Dysmetria
Mild spasticity
“lurching” or forward-falling movements
Staggering
Falling
Loss of muscle tone
Incoordination
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent menace
Other
May be associated with hydrocephalus
May be associated with storage diseases (Niemann-Pick type C)
Behavioral/Mental Awareness
Incessant crying
Posture and Appearance
Periodic opisthotonus
Vertical nystagmus
Positional nystagmus
Movement
Hypermetria
Pelvic limb stiffness
Pelvic limb ataxia
Inability to stand
Ataxia
Head tremor
Rolling on side
Unable to remain in a sternal position
Intention tremor
Dysmetria
Mild spasticity
“lurching” or forward-falling movements
Staggering
Falling
Loss of muscle tone
Incoordination
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent menace
Other
May be associated with hydrocephalus
May be associated with storage diseases (Niemann-Pick type C)
Cerebellum
Suspected autosomal recessive inheritance
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