Necrotizing Meningoencephalitis (NME)
Necrotizing meningoencephalitis (NME) is a non-infectious inflammatory condition under the spectrum of meningoencephalitis of unknown origin. In NME, the lymphoplasmacytic inflammation is primarily distributed throughout the deep cerebral white matter and diencephalon. The inflammation can be distributed bilaterally, but is often worse in one hemisphere.
Age of Onset: Typically occurs in animals less than 5 years of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs often present acutely and progress over time
Clinical signs often present acutely and progress over time
Clinical Signs:
Behavioral/Mental Awareness
Generalized seizures
Behavioral changes
Compulsive pacing
Movement
Head turning and circling
Ataxia/Abnormal gait
Proprioception
Proprioceptive deficit (contralateral)
Cranial Nerves
Facial hypalgesia (contralateral)
Menace deficit (contralateral)
Central vestibular signs (head tilt, nystagmus, vestibular strabismus)
Behavioral/Mental Awareness
Generalized seizures
Behavioral changes
Compulsive pacing
Movement
Head turning and circling
Ataxia/Abnormal gait
Proprioception
Proprioceptive deficit (contralateral)
Cranial Nerves
Facial hypalgesia (contralateral)
Menace deficit (contralateral)
Central vestibular signs (head tilt, nystagmus, vestibular strabismus)
Intracranial - Prosencephalon (deep white matter and diencephalon)
Unknown
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