Cerebellar Hypoplasia (Dandy Walker-like Malformation)
A congenital malformation that is defined by inadequate development of the cerebellum. Causes can range from genetic abnormalities to in-utero infection. Concurrent hydrocephalus and hydranencephaly may also occur. It has been reported in several dogs with no breed predilection.
Age of Onset: 3 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs typically do not worsen over time
Clinical signs typically do not worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Mental retardation
Seizures
Posture and Appearance
Tremors
Shaking
Tonic neck
Movement
Ataxia
Hypermetria, more apparent in hindlimbs
Circling
Stumbling
Falling
Rhythmic dorsoventral bobbing of the head and trunk during elevation of the head
Proprioception
Proprioceptice deficits
Cranial Nerves
Absent menace response
Nystagmus
Strabismus
Special Reflexes (e.g. cutaneous trunci)
Tonic eye reflexes
Other
May be associated with related vestibular abnormalities
Behavioral/Mental Awareness
Mental retardation
Seizures
Posture and Appearance
Tremors
Shaking
Tonic neck
Movement
Ataxia
Hypermetria, more apparent in hindlimbs
Circling
Stumbling
Falling
Rhythmic dorsoventral bobbing of the head and trunk during elevation of the head
Proprioception
Proprioceptice deficits
Cranial Nerves
Absent menace response
Nystagmus
Strabismus
Special Reflexes (e.g. cutaneous trunci)
Tonic eye reflexes
Other
May be associated with related vestibular abnormalities
Cerebellum
Autosomal recessive VLDLR gene mutation
For breed specific genetic testing, click the link below:
https://www.genomia.cz/en/test/kombi-eurasier/
www.genomia.cz/en/test/cerebellar-hypoplasia/
www.laboklin.co.uk/laboklin/showGeneticTest.jsp?testID=8260
For breed specific genetic testing, click the link below:
https://www.genomia.cz/en/test/kombi-eurasier/
www.genomia.cz/en/test/cerebellar-hypoplasia/
www.laboklin.co.uk/laboklin/showGeneticTest.jsp?testID=8260
To read more about this disease click below:
