Gangliosidosis Type 1 (GM1)
Gangliosidosis (GM1) is a deficiency in the enzyme beta-galactosidase which causes defects in the catabolism of gangliosides resulting in their accumulation in neuron lysosomes.
Age of Onset: Less than 7 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over time
Clinical signs worsen over time
Clinical Signs:
Posture and Appearance
Stunted growth
Movement
Ataxia
Dysmetria
Hypermetria
Head Tremor
Spastic Paraplegia or Tetraplegia
Cranial Nerves
Visual Impairment
Nystagmus
Decreased cranial nerve responses
Other
Blood smear (vacuolated leukocytes)
Radiographs (irregularly widended intervertebral disc space and femoral head abnormalities)
Posture and Appearance
Stunted growth
Movement
Ataxia
Dysmetria
Hypermetria
Head Tremor
Spastic Paraplegia or Tetraplegia
Cranial Nerves
Visual Impairment
Nystagmus
Decreased cranial nerve responses
Other
Blood smear (vacuolated leukocytes)
Radiographs (irregularly widended intervertebral disc space and femoral head abnormalities)
Diffuse CNS
Autosomal recessive mutation in the Beta-Galactosidase gene
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