Dyserythropoietic Anemia and Myopathy Syndrome (DAMS)
Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) is a form of centronuclear myopathy associated with concurrent dyserythropoietic anemia.
Age of Onset: Less than 6 months
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over time
Clinical signs worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Seizures
Posture and Appearance
Stunted growth
Movement
Exercise intolerance
Weakness
Pelvic limb gait abnormality (abducted stifles with hocks turned inward)
Bunny hopping gait with the pelvic limbs
Cranial Nerves
Difficulty opening and closing the mouth (trismus)
Special Functions (e.g. respiration; urination)
Regurgitation (megaesophagus)
Dysphagia
Painful Reactions
Pain on palpation of the muscles
Muscle Atrophy
Generalized muscle atrophy (appendicular and temporal muscles)
Other
CBC Findings: Non-regenerative microcytic hypochromic anemia with marked metarubrocytosis, target cells, acanthocytes
Dilated cardiomyopathy developed in some dogs
Behavioral/Mental Awareness
Seizures
Posture and Appearance
Stunted growth
Movement
Exercise intolerance
Weakness
Pelvic limb gait abnormality (abducted stifles with hocks turned inward)
Bunny hopping gait with the pelvic limbs
Cranial Nerves
Difficulty opening and closing the mouth (trismus)
Special Functions (e.g. respiration; urination)
Regurgitation (megaesophagus)
Dysphagia
Painful Reactions
Pain on palpation of the muscles
Muscle Atrophy
Generalized muscle atrophy (appendicular and temporal muscles)
Other
CBC Findings: Non-regenerative microcytic hypochromic anemia with marked metarubrocytosis, target cells, acanthocytes
Dilated cardiomyopathy developed in some dogs
Diffuse neuromuscular
Autosomal recessive inheritance (EHBP1L1 frameshift deletion)
For breed specific genetic testing, click the link below:
www.animalabs.com/shop/dog/dyserythropoietic-anemia-and-myopathy-syndrome-dams--english-springer-spaniel-type/
www.cagt.co.uk/product/dyserythropoietic-anemia-and-myopathy-syndrome-dams/
For breed specific genetic testing, click the link below:
www.animalabs.com/shop/dog/dyserythropoietic-anemia-and-myopathy-syndrome-dams--english-springer-spaniel-type/
www.cagt.co.uk/product/dyserythropoietic-anemia-and-myopathy-syndrome-dams/
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