Acral Mutilation Syndrome (Sensory Neuropathy)
Neuropathies have been reported that involve only the sensory nerves. With some sensory neuropathy animals may self-mutilate.
Age of Onset: Ranges from 2 to 12 months with an average of 4 months old, however, adult animals can sometimes be affected.
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
In dogs that self-mutilate clinical signs can worsen rapidly in unrestrained dogs which result in auto-amputation of the feet.
In dogs that self-mutilate clinical signs can worsen rapidly in unrestrained dogs which result in auto-amputation of the feet.
Clinical Signs:
Behavioral/Mental Awareness
Intense licking of feet
Biting feet
Posture and Appearance
Swollen paws
Reddened paws
Paronchyna
Palmar and plantar ulceration
Nail loss
Painless fractures
Digit amputation
Pups smaller than unaffected littermates
Movement
Walk or run without evidence of lameness
Pain Sensation
Lack of response to acral pinprick or compression
Acral analgesia
Deep pain response to toe pinch may be present
Analgesia of lips and pinnae may be present
Mild hyperesthesia in lumbosacral region may be presen
Behavioral/Mental Awareness
Intense licking of feet
Biting feet
Posture and Appearance
Swollen paws
Reddened paws
Paronchyna
Palmar and plantar ulceration
Nail loss
Painless fractures
Digit amputation
Pups smaller than unaffected littermates
Movement
Walk or run without evidence of lameness
Pain Sensation
Lack of response to acral pinprick or compression
Acral analgesia
Deep pain response to toe pinch may be present
Analgesia of lips and pinnae may be present
Mild hyperesthesia in lumbosacral region may be presen
Variable proximal extent. One or several feet may be affected.
Autosomal recessive inheritance of GDNF mutant
For breed specific genetic testing, follow the links below:
https://labogen.com/en/genetic-diseases-dog/acral-mutilation-syndrome-ams/
https://embarkvet.com/products/dog-health/health-conditions/hereditary-sensory-autonomic-neuropathy-acral-mutilation-syndrome-ams/
For breed specific genetic testing, follow the links below:
https://labogen.com/en/genetic-diseases-dog/acral-mutilation-syndrome-ams/
https://embarkvet.com/products/dog-health/health-conditions/hereditary-sensory-autonomic-neuropathy-acral-mutilation-syndrome-ams/
To read more about this disease click below:
