Neuronal Ceroid Lipofuscinosis
Neuronal ceroid lipofuscinosis are a group of lysosomal storage disorders characterized by intracellular accumulations resulting in progressive neuronal degeneration.
Age of Onset: 14-18 months of age
Sex Predisposition: Any sex of dog can be affected
Clinical Course:
Clinical signs slowly progress over time beginning with mental dullness progressing to convulsions and cardiac failure by 17-24 months of age.
Clinical signs slowly progress over time beginning with mental dullness progressing to convulsions and cardiac failure by 17-24 months of age.
Clinical Signs:
Behavioral/Mental Awareness
Seizures
Cognitive decline
Personality change
Aggression
Hyperactivity
Self-mutilation
Movement
Ataxia
Head tremors
Tetraparesis
Proprioception
Proprioceptive deficits
Cranial Nerves
Visual impairment
Behavioral/Mental Awareness
Seizures
Cognitive decline
Personality change
Aggression
Hyperactivity
Self-mutilation
Movement
Ataxia
Head tremors
Tetraparesis
Proprioception
Proprioceptive deficits
Cranial Nerves
Visual impairment
Intracranial - diffuse
Autosomal recessive CLN8 gene mutation
For breed specific genetic testing, click the link below:
https://embarkvet.com/products/dog-health/health-conditions/neuronal-ceroid-lipofuscinosis-8-ncl-8/www.genomia.cz/en/test/ncl-english-setter/
For breed specific genetic testing, click the link below:
https://embarkvet.com/products/dog-health/health-conditions/neuronal-ceroid-lipofuscinosis-8-ncl-8/www.genomia.cz/en/test/ncl-english-setter/
To read more about this disease click below:
