Cerebellar Abiotrophy/Cerebellar Cortical Abiotrophy/Cerebellar Cortical Degeneration/Cerebellar Degeneration
Cerebellar abiotrophy results from a loss of vital substance for continued life of the neuron. Many of these diseases are associated with loss of purkinje cells.
Age of Onset: 10-12 weeks of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs typically worsen over time
Clinical signs typically worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Incessant crying
Posture and Appearance
Periodic opisthotonus
Wide-based stance
Movement
Hypermetria
Pelvic limb stiffness
Pelvic limb ataxia
Inability to stand
Ataxia
Rolling on side
Unable to remain in a sternal position
Intention tremor
Dysmetria
Mild spasticity
“lurching” or forward-falling movements
Staggering
Loss of muscle tone
Proprioception
Proprioceptive deficits
Vertical nystagmus
Positional nystagmus
Cranial Nerves
Absent menace response
Behavioral/Mental Awareness
Incessant crying
Posture and Appearance
Periodic opisthotonus
Wide-based stance
Movement
Hypermetria
Pelvic limb stiffness
Pelvic limb ataxia
Inability to stand
Ataxia
Rolling on side
Unable to remain in a sternal position
Intention tremor
Dysmetria
Mild spasticity
“lurching” or forward-falling movements
Staggering
Loss of muscle tone
Proprioception
Proprioceptive deficits
Vertical nystagmus
Positional nystagmus
Cranial Nerves
Absent menace response
Cerebellum
Suspected autosomal recessive inheritance
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