Deafness with Vestibular Dysfunction
This is a congenital syndrome resulting in both hearing loss and vestibular dysfunction in Doberman Pinschers. This disease occurs as a result of progressive degeneration of sensory cells in the cochlea and vestibular organs.
Age of Onset: Clinical signs are present at birth
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs do not worsen over time. Deafness may be unilateral or bilateral
Clinical signs do not worsen over time. Deafness may be unilateral or bilateral
Clinical Signs:
Behavioral/Mental Awareness
Abnormal vocalization
Barking for a prolonged time
Loud vocalization
Unresponsive to vocal commands or auditory stimulus
Easily startled by physical stimulus
Movement
Circling
Ataxia
Cranial Nerves
Deafness
Head tilt
Behavioral/Mental Awareness
Abnormal vocalization
Barking for a prolonged time
Loud vocalization
Unresponsive to vocal commands or auditory stimulus
Easily startled by physical stimulus
Movement
Circling
Ataxia
Cranial Nerves
Deafness
Head tilt
Inner ear (cochlea), cochlear nerve, brainstem
Autosomal recessive mutation in the PTPRQ and MY07A genes
For breed specific genetic testing, click the link below:
MY07A-specific testing:
vgl.ucdavis.edu/test/dings-doberman
https://embarkvet.com/products/dog-health/health-conditions/deafness-and-vestibular-syndrome-of-dobermans-dvdob-dings/
PTPRQ-specific testing:
vgl.ucdavis.edu/test/dings-doberman
https://embarkvet.com/products/dog-health/health-conditions/unilateral-deafness-and-vestibular-syndrome/
For breed specific genetic testing, click the link below:
MY07A-specific testing:
vgl.ucdavis.edu/test/dings-doberman
https://embarkvet.com/products/dog-health/health-conditions/deafness-and-vestibular-syndrome-of-dobermans-dvdob-dings/
PTPRQ-specific testing:
vgl.ucdavis.edu/test/dings-doberman
https://embarkvet.com/products/dog-health/health-conditions/unilateral-deafness-and-vestibular-syndrome/
To read more about this disease click below:
