Spongiform Leukoencephalomyelopathy (associated with Parvoviral infection)
Spongiform leukoencephalopathy is a generalized progressive degenerative vacuolation of white matter of the brain and spinal cord. In Cretan Hounds, the development of leukoencephalopathy has been associated with parvoviral infection potentially suggesting genetic predisposition to this pathologic sequelae.
Age of Onset: 2-9 weeks of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over time. Clinical signs are often exacerbated during times of excitement and subside during periods of rest.
Clinical signs worsen over time. Clinical signs are often exacerbated during times of excitement and subside during periods of rest.
Clinical Signs:
Movement
Head and generalized whole body tremors
Ataxia
Paresis to paralysis
Limb spasticity
Movement
Head and generalized whole body tremors
Ataxia
Paresis to paralysis
Limb spasticity
White matter of the brain and spinal cord
Mitochondrial DNA sequencing showed a G to A transition at 14,474 nt (G14474A, GenBank accession no. NC_002008) that results in an amino acid change of valine-98 to methionine (V98M) of mitochondrial encoded cytochrome b. (Li et a. (2006)
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