Generalized Tremor (Idiopathic Tremor Syndrome/White Shaker Syndrome)
Generalized tremors can occur as a result of a variety of pathophysiologic processes, including hypomyelination, toxicities, electrolyte imbalances, or inflammatory central nervous system diseases.
Age of Onset: Less than 1 year of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Variable - With the inflammatory form (“Generalized tremor syndrome”) animals may initially have intermittent episodes with progress to persistent whole body tremors.
Tremors worsen with excitement, stress, or exercise and improve with sleep
Variable - With the inflammatory form (“Generalized tremor syndrome”) animals may initially have intermittent episodes with progress to persistent whole body tremors.
Tremors worsen with excitement, stress, or exercise and improve with sleep
Clinical Signs:
Behavioral/Mental Awareness
Altered behavior (restlessness, anxiousness, agitation, startling easily, skittishness, or disorientation)
Seizures
Posture and Appearance
Wide-based stance
Kyphosis
Movement
Diffuse whole body tremor
Ataxia
Hypermetria
Cranial Nerves
Vestibular signs such as head tilt and nystagmus
Extraocular muscle tremor resulting in rapid movements of the eye (opisoclonus) often mistaken for nystagmus
Reduced or absent menace response
Other
Gastrointestinal signs (poor appetite, lip smacking, ptyalism, vomiting)
Pyrexia
Behavioral/Mental Awareness
Altered behavior (restlessness, anxiousness, agitation, startling easily, skittishness, or disorientation)
Seizures
Posture and Appearance
Wide-based stance
Kyphosis
Movement
Diffuse whole body tremor
Ataxia
Hypermetria
Cranial Nerves
Vestibular signs such as head tilt and nystagmus
Extraocular muscle tremor resulting in rapid movements of the eye (opisoclonus) often mistaken for nystagmus
Reduced or absent menace response
Other
Gastrointestinal signs (poor appetite, lip smacking, ptyalism, vomiting)
Pyrexia
Diffuse central nervous system
Unknown
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