<Return to Disease List​

Hereditary Polyneuropathy/Neuropathy

• Description
• Signalment
• Clinical Features
• Neurolocalization
• Genetics

<

>

Hereditary polyneuropathy/neuropathy is an idiopathic degeneration of nerves often characterized by axonal degeneration and hypomyelination.

Age of Onset: 2-7 months of age

Sex Predisposition: Any sex of animal can be affected

Clinical Course:
​Clinical signs worsen over time

Clinical Signs:
Posture and Appearance
Wounds on the dorsal aspect of the paws

Movement
Collapse
Hyporeflexia
Progressive paraparesis to tetraparesis

Proprioception
Proprioceptive deficits

​Cranial Nerves
Absent palpebral reflex

Spinal Reflexes
Decreased spinal reflexes
Decreased patellar reflex
Absent panniculus reflex
Absent anal reflex (normal anal tone)

Special Functions (e.g. respiration; urination)
Exercise intolerance
Inspiratory stridor
Megaesophagus
Urinary incontinence (dribbling urine)

Muscle Atrophy
General muscle atrophy
Muscles of mastication (CN V)

Pain Sensation
Absent pain sensation of distal limbs

Other
Abnormal vocalization
Hyperesthesia​

Spinal cord

Autosomal recessive mutation in FAM134B gene

For breed specific genetic testing, follow the links below:
https://www.genomia.cz/en/test/sn/
​https://avian2.animalgenetics.com/Canine/Genetic_Disease/SN.asp

To read more about this disease click below:

References