Musladin‐Lueke Syndrome (Chinese Beagle Syndrome)
Musladin-Lueke Syndrome is a genetic disease of beagles affecting the connective tissue. Animals may demonstrate a variety of clinical signs, including gait changes and neurologic signs, depending on the systems affected and the extent of disease.
Age of Onset: 3 months - 2 years of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs typically stabilize after 1 year of life
Clinical signs typically stabilize after 1 year of life
Clinical Signs:
Behavioral/Mental Awareness
Seizures
Placid disposition
Posture and Appearance
Rigid extension of all limbs
Low tail carriage
Rigid tail tone
Broad skull
Characteristic ridge in ear cartilage
Carpus valgus
Thickened fur
Lateralize eyes
Movement
Gait abnormalities
Walking on "tiptoes)
Difficulty righting
Proprioception
Cranial Nerves
Spinal Reflexes
Special Reflexes (e.g. cutaneous trunci)
Special Functions (e.g. respiration; urination)
Painful Reactions
Muscle Atrophy
Pain Sensation
Other
Intermittent urinary incontinence
Behavioral/Mental Awareness
Seizures
Placid disposition
Posture and Appearance
Rigid extension of all limbs
Low tail carriage
Rigid tail tone
Broad skull
Characteristic ridge in ear cartilage
Carpus valgus
Thickened fur
Lateralize eyes
Movement
Gait abnormalities
Walking on "tiptoes)
Difficulty righting
Proprioception
Cranial Nerves
Spinal Reflexes
Special Reflexes (e.g. cutaneous trunci)
Special Functions (e.g. respiration; urination)
Painful Reactions
Muscle Atrophy
Pain Sensation
Other
Intermittent urinary incontinence
Muscle
Autosomal recessive inheritance of ADAMTSL2 gene
For breed specific genetic testing, follow the links below:
https://vgl.ucdavis.edu/test/musladin-lueke-syndrome
https://www.kokogenetics.com/en/results/pet-health-test/musladin-lueke-syndrome?srsltid=AfmBOopjvT7QV3u0f8lCd6RuA7OClkWvLf6cb2aaVitqenxS2TbfLrTD
For breed specific genetic testing, follow the links below:
https://vgl.ucdavis.edu/test/musladin-lueke-syndrome
https://www.kokogenetics.com/en/results/pet-health-test/musladin-lueke-syndrome?srsltid=AfmBOopjvT7QV3u0f8lCd6RuA7OClkWvLf6cb2aaVitqenxS2TbfLrTD
To read more about this disease click below:
