Fibrinoid Leukodystrophy (Fibrinoid Encephalomyelopathy/Alexander Disease/Rosenthal Fiber Myelopathy)
An extremely rare primary degeneration of nervous elements with a range of clinical signs and disease patterns.
Age of Onset: 3-6 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs may worsen over time
Clinical signs may worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Alterations in personality or behavior
Mild drowsiness
Posture and Appearance
Tremor
Head tilt
Opisthotonos
Movement
Ataxia
Incoordination
Drifting to the side
Wide excursions of the head
Proprioception
Knuckling on all limbs
Slow postural reflexes
Cranial Nerves
Reduced menace response
Nystagmus
Behavioral/Mental Awareness
Alterations in personality or behavior
Mild drowsiness
Posture and Appearance
Tremor
Head tilt
Opisthotonos
Movement
Ataxia
Incoordination
Drifting to the side
Wide excursions of the head
Proprioception
Knuckling on all limbs
Slow postural reflexes
Cranial Nerves
Reduced menace response
Nystagmus
The classic histologic lesion consists of so-called Rosenthal fibers distributed around the vessels in the white matter, subpial, and subependymal areas.
Suspected autosomal dominant mutation in canine orthologue of glial fibrillary acidic protein (GFAP) gene
For breed specific genetic testing, follow the link below:
https://www.wisdompanel.com/en-us/dog-health-conditions/alexander-disease#:~:text=This%20disease%20is%20autosomal%20recessive,different%20genetic%20or%20clinical%20cause.
For breed specific genetic testing, follow the link below:
https://www.wisdompanel.com/en-us/dog-health-conditions/alexander-disease#:~:text=This%20disease%20is%20autosomal%20recessive,different%20genetic%20or%20clinical%20cause.
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