Meningoencephalitis of Unknown Origin (MUO)
Meningoencephalitis of unknown origin is characterized by immune-mediated inflammation of the central nervous system with no identifiable cause.
Age of Onset: any age of dog can be affected; however onset at 7-11 years of age was most common in this breed
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs may worsen over time
Clinical signs may worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Abnormal vocalization
Aggression
Decreased mentation/obtundation
“Dull”
Excitation
Restlessness
Seizures
Sleepiness
Posture and Appearance
Head tilt
Movement
Ataxia
Circling
Paresis
Tremors
Weakness
Proprioception
Proprioceptive deficits
Cranial Nerves
Cranial nerve deficits
Nystagmus
Reduced menace response
Painful Reactions
Pain on palpation of the cervical spine
Behavioral/Mental Awareness
Abnormal vocalization
Aggression
Decreased mentation/obtundation
“Dull”
Excitation
Restlessness
Seizures
Sleepiness
Posture and Appearance
Head tilt
Movement
Ataxia
Circling
Paresis
Tremors
Weakness
Proprioception
Proprioceptive deficits
Cranial Nerves
Cranial nerve deficits
Nystagmus
Reduced menace response
Painful Reactions
Pain on palpation of the cervical spine
Intracranial
Unknown
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