Spongiform Leukoencephalomyelopathy
Spongiform leukoencephalopathy is a generalized progressive degenerative vacuolation of white matter of the brain and spinal cord.
Age of Onset: 2-9 weeks of age (Males have been reported to be affected earlier than females)
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over time
Clinical signs worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Seizures
Movement
Generalized whole body tremors
Ataxia
Paresis to paralysis
Limb spasticity
Proprioception
Absent postural reactions (thoracic limbs > pelvic limbs)
Cranial Nerves
Cranial nerve dysfunction (dropped jaw, hypoglossal dysfunction, nystagmus)
Absent menace response
Vision and audition remain intact
Special Functions (e.g. respiration; urination)
Dysphagia
Excessive salivation
Other
Failure to grow
Behavioral/Mental Awareness
Seizures
Movement
Generalized whole body tremors
Ataxia
Paresis to paralysis
Limb spasticity
Proprioception
Absent postural reactions (thoracic limbs > pelvic limbs)
Cranial Nerves
Cranial nerve dysfunction (dropped jaw, hypoglossal dysfunction, nystagmus)
Absent menace response
Vision and audition remain intact
Special Functions (e.g. respiration; urination)
Dysphagia
Excessive salivation
Other
Failure to grow
White matter of the brain and spinal cord
Mitochondrial DNA cytochrome b gene mutation (maternal inheritance pattern)
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