Neuronal Ceroid Lipofuscinosis
Neuronal ceroid lipofuscinosis are a group of lysosomal storage disorders characterized by intracellular accumulations resulting in progressive neuronal degeneration.
Age of Onset: Two forms of NCL exist in australian cattle dogs:
Early-onset: occuring in dogs less than 2 years of age
Late-onset: occuring in dogs older than 6 years of age
Early-onset: occuring in dogs less than 2 years of age
Late-onset: occuring in dogs older than 6 years of age
Sex Predisposition: Any sex of dog can be affected
Clinical Course:
Clinical signs slowly progress over the source of 1-2 years. After years of progression the dog may be unable to stand or walk.
Clinical signs slowly progress over the source of 1-2 years. After years of progression the dog may be unable to stand or walk.
Clinical Signs:
Behavioral/Mental Awareness
Seizures
Personality change
Aggressive or fearfull behavior
Hyperactivity
Loss of learned behavior
"Trance"-like behavior
Propulsive circling
Increased sensitivity to loud or unexpected sounds
Sleep disturbances
Movement
Ataxia
Head tremors
Tetraparesis
Proprioception
Proprioceptive deficits
Cranial Nerves
Visual impairment
Absent menace response
Strabismus
Verical nystagmus
Behavioral/Mental Awareness
Seizures
Personality change
Aggressive or fearfull behavior
Hyperactivity
Loss of learned behavior
"Trance"-like behavior
Propulsive circling
Increased sensitivity to loud or unexpected sounds
Sleep disturbances
Movement
Ataxia
Head tremors
Tetraparesis
Proprioception
Proprioceptive deficits
Cranial Nerves
Visual impairment
Absent menace response
Strabismus
Verical nystagmus
Intracranial - diffuse
Early-onset: Autosomal recessive mutation in the CLCN5 gene
Late-onset: Autosomal recessive mytation in the ATP13A2 gene
For breed specific testing, follow the links below:
https://www.combibreed.com/neuronal-ceroid-lipofuscinosis-12-ncl-12-australian-cattle-dog/
https://www.animalabs.com/shop/dog/neuronal-ceroid-lipofuscinosis-12-ncl12--australian-cattle-dog-type/
https://www.genomia.cz/en/test/ncl12/
https://embarkvet.com/products/dog-health/health-conditions/late-onset-neuronal-ceroid-lipofuscinosis-ncl-12/
Late-onset: Autosomal recessive mytation in the ATP13A2 gene
For breed specific testing, follow the links below:
https://www.combibreed.com/neuronal-ceroid-lipofuscinosis-12-ncl-12-australian-cattle-dog/
https://www.animalabs.com/shop/dog/neuronal-ceroid-lipofuscinosis-12-ncl12--australian-cattle-dog-type/
https://www.genomia.cz/en/test/ncl12/
https://embarkvet.com/products/dog-health/health-conditions/late-onset-neuronal-ceroid-lipofuscinosis-ncl-12/
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