(Leigh-Like) Subacute Necrotizing Encephalopathy
Subacute necrotizing encephalopathy is a mitochondrial disorder characterized by multifocal cerebrocortical and cerebellar necrosis with vascular proliferation.
Age of Onset: 6-8 weeks of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs are rapidly progresive
Clinical signs are rapidly progresive
Clinical Signs:
Behavioral/Mental Awareness
Disorientation
Reduced mental state
Seizures
Posture and Appearance
Postural deficits
Movement
Ataxia
Paresis
Gait abnormalities
Head bobbing
Cranial Nerves
Nystagmus
Strabismus
Head tilt
Behavioral/Mental Awareness
Disorientation
Reduced mental state
Seizures
Posture and Appearance
Postural deficits
Movement
Ataxia
Paresis
Gait abnormalities
Head bobbing
Cranial Nerves
Nystagmus
Strabismus
Head tilt
Intracranial
Autosomal recessive: Loss-of-function mutation in SLC19A3 gene
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