Juvenile-Onset Polyneuropathy/Familial Nodo-Paranodal Polyneuropathy
Familial Nodo-paranodal polyneuropathy is an early onset neurodegenerative disorder of dogs.
Age of Onset: Early-onset; 1-6 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs begin with inspiratory dyspnea and ultimately progress to locomotor signs. Clinical signs are slowly progressive
Clinical signs begin with inspiratory dyspnea and ultimately progress to locomotor signs. Clinical signs are slowly progressive
Clinical Signs:
Posture and Appearance
Plantigrade/Palmigrade stance
Movement
Gait abnormalities
High-stepping gait
Ambulatory tetraparesis
Ataxia (pelvlic limbs > thoracic limbs)
Proprioception
Delayed postural reactions
Spinal Reflexes
Hyporeflexia
Special Functions (e.g. respiration; urination)
Laryngeal paralysis
Inspiratory stridor
Dyspnea
Regurgitation
Painful Reactions
Cutaneous hypoalgesia
Muscle Atrophy
Appendicular muscle atrophy
Posture and Appearance
Plantigrade/Palmigrade stance
Movement
Gait abnormalities
High-stepping gait
Ambulatory tetraparesis
Ataxia (pelvlic limbs > thoracic limbs)
Proprioception
Delayed postural reactions
Spinal Reflexes
Hyporeflexia
Special Functions (e.g. respiration; urination)
Laryngeal paralysis
Inspiratory stridor
Dyspnea
Regurgitation
Painful Reactions
Cutaneous hypoalgesia
Muscle Atrophy
Appendicular muscle atrophy
Peripheral nerves- mutlifocal
Suspected autosomal recessive inheritance
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