Methionine Deficiency-Related Myelinopathy (Hound Ataxia)
Methionine Deficiency-Related Myelinopathy is caused by insufficient methionine (an essential amino acid) which is a building block for protein synthesis. The lack of methionine results in degeneration of the white matter in the spinal cord
Age of Onset: 2-5 years of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs may worsen over the course of a few years
Clinical signs may worsen over the course of a few years
Clinical Signs:
Movement
Exaggerated retraction of pelvic limbs
Pelvic limb hypertonicity
Pelvic limb Incoordination
Weakness
Proprioception
Depressed pelvic limb proprioception
Special Reflexes (e.g. cutaneous trunci)
Abnormal panniculus reflex (caudal to the mid-thoracic/rostral lumbar segments)
Movement
Exaggerated retraction of pelvic limbs
Pelvic limb hypertonicity
Pelvic limb Incoordination
Weakness
Proprioception
Depressed pelvic limb proprioception
Special Reflexes (e.g. cutaneous trunci)
Abnormal panniculus reflex (caudal to the mid-thoracic/rostral lumbar segments)
Spinal cord
Unknown
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