Spinal Dysraphism (Myelodysplasia)
Myelodysplasias are congenital spinal cord developmental abnormalities. Specifically, spinal dysraphism occurs due to an incomplete formation of the dorsal median septum, ventral median fissure, hydromyelia or absent central canal or failure of ventral gray column cell body migration.
Age of Onset: Congenital (Signs are first observed when the dogs begin to walk)
However, in the case report by Vishniw et al. (1994), the dog did not present with clinical signs until 3 years of age
However, in the case report by Vishniw et al. (1994), the dog did not present with clinical signs until 3 years of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs do not worsen over time
*In this case the late course of onset is hypothesized to be due to a secondary event altering CSF dyanamics within the dysplastic spinal cord, resulting in fluid accumulation in the adjacent neuroparenchyma (syrinx) and susequent neurologic deficits.
Clinical signs do not worsen over time
*In this case the late course of onset is hypothesized to be due to a secondary event altering CSF dyanamics within the dysplastic spinal cord, resulting in fluid accumulation in the adjacent neuroparenchyma (syrinx) and susequent neurologic deficits.
Clinical Signs:
Behavioral/Mental Awareness
Stuporous
Movement
Bunny hopping (simultaneous) gait in pelvic limbs
Paraparesis
Ataxia (gait deficits were symmetrical and similar in all limbs)
Muscle Atrophy
Mild bilateral atrophy of thoracic limb muscles (supraspinatus, infraspinatus, biceps brachii, and brachialis muscles)
Pain Sensation
Non-specific cutaneous hyperesthesia
Behavioral/Mental Awareness
Stuporous
Movement
Bunny hopping (simultaneous) gait in pelvic limbs
Paraparesis
Ataxia (gait deficits were symmetrical and similar in all limbs)
Muscle Atrophy
Mild bilateral atrophy of thoracic limb muscles (supraspinatus, infraspinatus, biceps brachii, and brachialis muscles)
Pain Sensation
Non-specific cutaneous hyperesthesia
Spinal (Thoracolumbar)
Unknown
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